Seth MacFarlane is best known for creating TV shows Family Guy and American Dad. Family Guy has been a cult hit for the last several years and has kept The Simpsons on their heels. In this commercial, MacFarlane busts out his Stewie Griffin, Peter Griffin, Quagmire, and Roger the Alien voice. MacFarlane is the highest paid TV writer and producer in history at about $100 million.
MacFarlane is signed a deal last June with Google to put together a series of advertisements called Calvacade of Cartoon Comedy. My personal favorite is the Super Mario skit.