BNGO Stock Price Increased 156.48% This Past Week: Why It Happened

By Amit Chowdhry ● January 5, 2021
  • The stock price of BioNano Genomics Inc (NASDAQ: BNGO) has increased by 156.48% this past week. This is why it happened.

The stock price of BioNano Genomics Inc (NASDAQ: BNGO) has increased by 156.48% this past week. One of the bullish triggers for the stock price this past week has to do with an announcement about a publication in the Journal of Personalized Medicine by Lineagen (its CLIA certified diagnostic services subsidiary) of an analysis of Professor Temple Grandin’s genome in one of the most comprehensive evaluations of a single genome of a high functioning individual with Autism Spectrum Disorder (ASD). 

And through use of the Lineagen’s suite of genetic tests customized for individuals with ASD and other disorders of childhood development, including FirstStepDx PLUS chromosomal microarray, NextStepDx PLUS whole exome sequencing, and whole genome sequencing, the study identified novel variants in known ASD risk genes and other genetic variants important to her health and wellness. 

Dr. Grandin was diagnosed with ASD during childhood and was non-verbal until age 3. And she avoided physical touch and had difficulties with social interactions as an adolescent, but she was able to develop a career as a world-renowned PhD scientist and authored the books “The Autistic Brain” and “Thinking in Pictures.” Along with having ASD, she also experienced a lifelong history of feeling heat and pain (specifically in her feet), insomnia, anxiety and panic attacks and is missing several teeth but elected to forego dental implants.

Lineagen’s genome analysis had identified sequence variants in 3 ASD risk genes, one of which was initially discovered and validated by Lineagen, and structural variants in other neurodevelopmental genes that, while not considered diagnostic on their own — in combination — could explain her ASD and related health conditions. And pathogenic variants were found in genes that explain her symptoms of pain (familial Mediterranean fever) and missing teeth (ectodermal dysplasia). 

Her decision to forego dental implants was the right one given the bone weakness caused by ectodermal dysplasia. And analysis of pharmacogenetic genes found her to have a slow metabolism of many drugs, including Warfarin – which meant that her prescriptions and dosage had to be adjusted. Without this critical information, there could have been significant bleeding-related issues during surgery.

KEY QUOTES:

“When I originally requested to have genetic testing, I had no idea that the test I was getting for autism information would provide me with valuable information for other health problems. It is clearly beneficial for individuals to undergo genetic testing. Those with autism, like myself, may learn important information to guide medical decisions that may possibly save their lives while also potentially finding a genetic link to autism. Testing for people with autism was not commonplace in my youth or early adulthood, which is too bad, because this practice will push the medical community’s understanding of autism and health risks forward.”

— Dr. Grandin 

“This publication shows the importance of genetic testing for ASD and neurodevelopmental disorders. ASD is typically diagnosed based on a child’s behavior, and only 3% of children with an ASD diagnosis get clinical genetic testing, which is recommended by a number of professional medical organizations including the American College of Medical Genetics and Genomics and the American Academy of Pediatrics. Widespread adoption of genetic testing is important to patients and families because it creates a better understanding of ASD, but more importantly, informs families and patients about immediate health risks associated with ASD that could personalize treatment options and provide potentially life-saving information.”

“We are grateful to Dr. Grandin for her willingness to participate in this study. Now that Lineagen has become a part of Bionano Genomics, we are expanding this study in a next phase to include a full analysis of her genome using optical genome mapping (OGM) with Saphyr. The wide spectrum of genetic variation between individuals with ASD makes it difficult for traditional tests to provide a diagnosis of the genetic condition. We expect OGM with Saphyr to reveal a more complete picture of genomic variants that provides actionable information that can potentially improve outcomes.”

— Erik Holmlin, PhD, CEO of Bionano Genomics

Stock Analysis:

While the stock price increase of BioNano Genomics this past week is compelling, it is pretty volatile. Since September 2018, the stock price fell over 29%. But it is up more than 289% over the past year and it dropped over 31% today. So if you decide to invest in this stock, then be prepared to go on a wild ride. 

Disclaimer: This content is intended for informational purposes. Before making any investment, you should do your own analysis.