VXRT Stock: From $8.02 To $9.48 (18.2% Increase) Pre-Market Explanation

By Amit Chowdhry ● May 4, 2021
  • The stock price of Vaxart Inc (NASDAQ: VXRT) increased from $8.02 to $9.48 (up 18.2%) pre-market. This is why it happened.

The stock price of Vaxart Inc (NASDAQ: VXRT) – a clinical-stage biotechnology company developing oral recombinant vaccines that are administered by tablet rather than by injection – increased from $8.02 to $9.48 (up 18.2%) pre-market. Investors are responding positively to Vaxart announcing at the company’s key opinion leader event that new data obtained from its Phase I COVID-19 trial added to the evidence suggesting that VXA-CoV2-1 (the company’s first COVID-19 oral vaccine construct that triggers mucosal immunity and includes both the S and the N SARS-Cov-2 proteins) has broad cross-coronavirus activity.

The Phase I open-label study is intended to evaluate the safety and immunogenicity of Vaxart’s vaccine candidate. And data obtained from Vaxart’s oral COVID-19 vaccine Phase I trial showed substantial CD8+ T-cell responses as measured by IFN-g and TNF-a induction. 

In a comparative experiment conducted by Vaxart, the Phase I study data was compared to T-cell responses from volunteers subsequently vaccinated with the Moderna or Pfizer mRNA vaccine, indicating the mRNA vaccines induced fewer T-cell responses.

In his presentation, Dr. Tucker had discussed:

— Vaxart’s vaccine candidate showed higher CD8+ T-cell responses than the Pfizer and Moderna vaccines

— Higher T-cell responses correlated to protection against COVID disease in a prospective Phase I study of first responders

— The Vaxart vaccine candidate elicited a T cell response against SARS-Cov-2, as well as showed cross-reactivity against diverse endemic coronaviruses like 229E, NL63, HKU1, and OC43

— N protein responses to SARS-CoV-1 have been shown to last 17 years after infection and cross-react to SARS-CoV-2

— Vaxart’s vaccine candidate triggered specific IgA antibodies in the mucosa. These mucosal IgA responses appeared to be cross-reactive against other coronaviruses like SARS-CoV-1, MERS, and the endemic common cold viruses 229E, NL63, HKU1, and OC43

KEY QUOTES:

“We have previously announced study data showing that our oral vaccine could be as protective as the leading injectable against flu, and that it does so by triggering a very different immune response. Data obtained from the Phase I study were compared to data from volunteers subsequently vaccinated with the Moderna or Pfizer mRNA vaccine distributed under emergency use authorizations (EUAs) and suggest that the same may be true against coronavirus. Our vaccine’s immune response appears very different that that seen from the leading injectables: mucosal antibodies rather than serum antibodies, and more potent T-cell responses. For our first oral COVID-19 vaccine candidate, we believe that these differences in immunogenicity profile may have a benefit in cross-reactive protection.” 

“We measured the T-cell responses in 9 volunteers vaccinated with the mRNA vaccines under EUAs and compared them in the same assays at the same timepoints to T-cell responses induced in subjects participating in our clinical trial (N=26 paired samples, or N=7 in the sub-study). Our vaccine appeared to produce CD8+ T-cell responses of a higher magnitude,” said Dr. Sean Tucker, chief scientific officer at Vaxart. “CD8+ T-cells produced by our vaccine can recognize and are capable of destroying cells infected with the virus, including in the mucosa. If you are effective at killing the virus-infected cells in the upper respiratory tract, you may be more likely to recover quicker or have a very mild course of infection. The strength of T-cell responses against both S and N proteins, which we targeted, leads us to believe that VXA-CoV2-1 offers a promising solution to variants.”

— Andrei Floroiu, Vaxart’s chief executive officer

Disclaimer: This content is intended for informational purposes. Before making any investment, you should do your own analysis.