Cadence announced that it has raised $100 million in Series C funding to scale its AI-powered chronic care platform for older adults. The funding round was led by Spark Capital. Thrive Capital, General Catalyst, Coatue, B Capital, Corewell Health Ventures, Memorial Hermann, and Duke Health also participated in the round.
Cadence is a clinical AI company focused on managing chronic care for older adults. The company’s platform is designed to support patients between clinic visits by using supervised AI agents to monitor patient vitals, identify risks early, support timely medication adjustments, and enable personalized lifestyle coaching.
The company said the new investment will help scale its AI agents to meet the needs of more than 56 million older adults living with chronic disease as the healthcare system faces a deepening clinician shortage.
Along with the funding, Cadence also announced new affiliations with Duke Health and Texas Health Resources. Duke Health is an academic health system serving patients across North Carolina, while Texas Health Resources is a nonprofit health system that cares for more patients in North Texas than any other provider.
Cadence now works with more than 20 leading health systems and treats over 100,000 active patients. The company said it has demonstrated clinical improvements in peer-reviewed literature and saves Medicare about $2.7 million every week. Cadence also tripled its annual recurring revenue in 2025.
Cadence’s Clinical Intelligence platform is integrated directly into partner health systems’ medical groups, electronic medical records, and clinical workflows. The system is designed to help clinicians manage chronic disease more efficiently by automating routine and high-volume care tasks while keeping clinicians focused on decisions that require human judgment.
The company is addressing one of the largest cost drivers in American healthcare: chronic disease. Cadence said its model is intended to extend the clinical workforce while reducing costs that accumulate when chronic conditions go unmanaged between visits.
Cadence also reported that its median response time for incoming vitals alerts is now 3.5 minutes, with 55% resolved appropriately without the need for human adjustment.
Across peer-reviewed studies and real-world deployments, Cadence’s model has produced several validated outcomes, including a 230% increase in heart failure patients on guideline-directed medical therapy, a 70% relative increase in blood pressure control for hypertension patients, a 27% reduction in hospital admissions, and a $1,302 per-patient annual reduction in total cost of care.
With the new capital, Cadence plans to expand across new health systems, advance its AI agents, and grow its value-based care models.
KEY QUOTES:
“We believe the most consequential AI companies of the next decade will be built in categories where the technology changes the underlying mechanics of the business. Cadence has done the hardest work first – demonstrating clinical outcomes, building trust with the country’s leading health systems, and proving out the safe and effective deployment of AI inside care delivery.”
“There is no other AI care platform in the country with this combination of scale, peer-reviewed clinical outcomes, and economic proof.”
Will Reed, Partner at Spark Capital and Cadence Board Member
“At Duke Health, our mission is to advance the health of our patients and the communities we serve. The moments that matter most for a patient’s health often happen at home, not in the clinic.”
“With Cadence, we stay connected to patients with chronic conditions around the clock, monitoring their health continuously so we can intervene early and keep them healthy. Together, we’re reimagining what care can be: healthier patients and a stronger, more affordable health system for all.”
Jeffrey Ferranti, MD, MS, Senior Vice President and Chief Digital Officer of Duke Health
“We built Cadence to solve the clinical labor constraint at the heart of the chronic disease crisis. Our AI automates care under close supervision, guided by our medical group, governed by our health system clinical protocols, and reimbursed through billing infrastructure and at-risk contracts.”
“We’re treating 100,000 patients with that system today, alongside partners committed to changing the status quo in chronic care. This investment builds the infrastructure to treat millions.”
Chris Altchek, Founder and CEO of Cadence
