Generate:Biomedicines: $273 Million Received For Advancing Generative AI Of Protein Therapeutics

By Amit Chowdhry • Sep 19, 2023

Generate:Biomedicines – a clinical-stage biotherapeutics company pioneering a machine-learning-powered generative biology platform – recently announced that it has raised $273 million in Series C financing. This funding round attracted many new investors, including Amgen; NVentures, NVIDIA’s venture capital arm; MAPS Capital (Mirae Asset Group); and Pictet Alternative Advisors. Additionally, company founder, Flagship Pioneering, and every Series B investor, including a wholly-owned subsidiary of the Abu Dhabi Investment Authority (ADIA); Fidelity Management & Research Company; funds and accounts advised by T. Rowe Price Associates; ARCH Venture Partners; and March Capital participated in the round.

Since the company’s Series B financing round in 2021, Generate:Biomedicines made notable progress as a leader in generative biology. Specific achievements include:

1.) Initiated its first-in-human trial for GB-0669 – a monoclonal antibody targeting a highly conserved region of the spike protein – in SARS-CoV-2. The insights gleaned from these efforts enable the company to respond to future pandemics and develop more effective treatments targeting COVID variants.

2.) Positioned for filing a Clinical Trial Application by early Q4 2023 for its anti-TSLP monoclonal antibody in asthma – which is expected to enter clinical trials shortly after that.

3.) Entered into collaboration agreements with Amgen and The University of Texas MD Anderson Cancer Center.

4.) Expanded The Generate Platform into new modalities, including into bi-specifics, enzymes, T-cell engagers, and cell therapy, and achieved the structural confirmation of its first de novo generated binders.

5.) Built an exceptional and diverse team of over 280 highly talented and motivated employees.

Generate:Biomedicines has a pipeline of 17 programs in preclinical and clinical development across oncology, immunology, and infectious disease. The company will leverage Series C funding to further its pipeline, including filing multiple INDs in 2024 and initiating multiple clinical trials annually thereafter. Additionally, the company will fully validate the breadth of its platform capabilities and establish its leadership in de novo therapeutic development.


“Our Series C round further propels The Generate Platform to increase significantly the precision, speed, and probability of success of novel therapeutics – positioning us to tackle even more complex targets and unmet patient needs. With our first program now in the clinic and multiple programs expected to enter clinical studies over the next couple of years, we are beginning to realize the enormous potential of generative biology to save and improve the lives of patients in areas where the burden of disease is greatest.”

— Mike Nally, Chief Executive Officer of Generate:Biomedicines

“We are thrilled to have the support of so many investors who believe in our ability to pioneer a new era of programmable protein-based therapeutics using generative AI. The closing of our Series C financing provides us with a multi-year cash runway and will further enhance our ability to invest aggressively in The Generate Platform, pioneer growth through new program starts, advance multiple programs through clinical trials, and opportunistically consider additional value-creating collaborations.”

— Jason Silvers, M.D., Chief Financial Officer of Generate:Biomedicines

“Since its founding, Generate:Biomedicines has worked diligently to turn biology into a truly engineerable discipline, transforming therapeutic development from a probabilistic endeavor to a deterministic one. The company has made significant advancements over the last five years, and I am confident this funding will enable us to realize a future where drug development is no longer a game of chance.”

— Noubar Afeyan, Ph.D., Co-founder and Chairman of the Board for Generate:Biomedicines and Founder and Chief Executive Officer of Flagship Pioneering