Hyro, a leading Responsible AI Agent Platform for healthcare, announced it has raised $45 million in a strategic growth round led by Healthier Capital, with participation from Norwest and Define Ventures, alongside existing backers. Strategic investors Bon Secours Mercy Health and ServiceNow Ventures also joined the round. The funding comes just 10 months after Hyro’s previous raise, doubling the company’s valuation and bringing total capital raised to $95 million.
The new investment will fuel Hyro’s continued expansion and product innovation as the company scales its suite of administrative, operational, and clinical AI agents designed to simplify patient access and enhance efficiency across digital and voice channels.
Hyro’s platform is currently deployed across more than 45 leading health systems, including Sutter Health, Tampa General Hospital, Prisma Health, and Piedmont Healthcare. Over 30 million patients in the U.S. are already engaging with Hyro’s conversational AI solutions, which payers and specialty clinic groups increasingly use.
The company’s latest innovation, Proactive Px, broadens Hyro’s platform to support bi-directional, omnichannel communication—enabling health systems to engage patients across inbound and outbound touchpoints proactively. This development comes amid an industry-wide push for digital-first care experiences, as patients demand real-time access and providers face continued staffing shortages and operational constraints.
Hyro distinguishes itself from newer AI startups by combining advanced Large Language Models (LLMs) with its proprietary conversational engine, featuring healthcare-specific Small Language Models (SLMs) and knowledge graphs. This hybrid approach enables the company’s agents to autonomously handle up to 85% of routine interactions, including registration, routing, scheduling, and prescription management, while ensuring HIPAA compliance and deep interoperability with EHRs like Epic and leading CRM systems.
By securely integrating into healthcare tech stacks through API connections, Hyro’s AI agents can autonomously perform tasks such as appointment booking and prescription refills. When necessary, the system transitions seamlessly to live human agents, maintaining a balance between automation and human support. These interactions are tracked in Hyro’s Patient Intelligence Dashboard, providing clients with visibility into performance and operational impact.
How the funding will be used: With this new funding, Hyro plans to accelerate adoption across additional healthcare segments, expanding its reach and deepening its integration within existing provider networks. The round underscores the industry’s growing confidence in the role of responsible, enterprise-grade AI solutions to address healthcare’s operational and accessibility challenges.
KEY QUOTES:
“After another 10 months of strong execution, landing new enterprise customers and expanding relationships with existing ones, we decided to bring on additional capital to further our mission of improving patient access to care and driving operational excellence for health systems. There are plenty of impressive demos in the market, but what healthcare organizations need are AI agents that are patient-ready and enterprise-ready today, designed around proven real-world workflows and best practices, deeply interoperable with EMR systems like Epic, and reinforced with robust safeguards. This new funding round reflects the industry’s growing trust in our approach. With support from both new strategic investors and long-time partners, we’re well-positioned to expand across new specialties and segments throughout the healthcare ecosystem.”
Israel Krush, CEO and Co-Founder of Hyro
“Hyro is delivering better levels of access, experience, and operational performance to leading healthcare organizations, delivering significant returns-on-investment. Hyro’s team, technology, traction and client-earned trust demonstrates an ability to deliver significant positive impacts at scale in healthcare.”
Amir Dan Rubin, CEO & Founding Managing Partner of Healthier Capital
“Healthcare is highly complex. What excites us about Hyro is their combination of advanced AI agents with deep healthcare-native design and safety mechanisms. Healthcare organizations need more than just polished chatbots, they need platforms that integrate seamlessly with EHRs, CRMs and clinical workflows embedded deep within the complex U.S. care ecosystem. Hyro is already proving it can deliver this at scale, and we believe it’s positioned to become the definitive AI communications layer for healthcare.”
Assaf Harel, Partner at Norwest
“Bon Secours Mercy Health has partnered with Hyro for more than five years, and we’re excited to build on that foundation by further expanding its latest AI-powered scheduling capabilities in our call center later this year.”
Staci Lucius, President of the Medical Group, Urgent Care, & Employer Services at Bon Secours Mercy Health
“Accrete Health Partners’ strategic investment in Hyro demonstrates Bon Secours Mercy Health’s commitment to supporting technologies that improve patient access through meaningful collaboration.”
Cyril Philip, Vice President of Digital Ventures at Bon Secours Mercy Health and Accrete Health Partners
