Insamo – a biotechnology company pioneering the discovery of membrane-permeable and orally available cyclic peptides – announced $12 million in seed capital from Playground Global, venBio, and MRL Ventures Fund (MRLV). Sahsen Ventures, BEVC, Civilization Ventures, and Axial Ventures also participated in the recent financing.
MRLV is a corporate venture arm of Merck – which invests in early-stage, preclinical therapeutics companies. And as part of the funding, Matt Hershenson, co-founder, Playground Global, and Corey Goodman, Ph.D, co-founder, venBio, will join the company’s Board of Directors.
Since being founded in 2022, CEO Timothy Craven, Ph.D., MBA, CSO Toby Passioura, Ph.D., and COO Glen Mcintyre, Ph.D. have been developing a platform to revolutionize drug discovery by combining ML-driven molecular design, ultra-high-throughput molecular biology, and parallel synthetic chemistry to identify preclinical candidates that exhibit favorable pharmacological properties rapidly.
And the objectives encompass enhancing patient care by replacing injected or infused biologics with easily administered oral cyclic-peptide formulations and driving rapid drug discovery for currently intractable drug targets. Their turn-key solution has the remarkable capability to generate treatment candidates from scratch consistently, regardless of prior knowledge about the disease target’s structure, dynamics, or ‘druggable’ sites. It requires only a small vial of the target material.
KEY QUOTES:
“Insamo’s mission is to transform how we discover drugs for some of the most challenging diseases. Macrocyclic peptides have been challenging to translate into the clinic. But we’re changing that. Our innovative ML tools and screening technologies drive our ability to rapidly optimize drug efficacy. With our recent funding, we’re poised to explore the full capabilities of these molecules and tackle breakthroughs in diseases once considered untreatable. Our platform’s pioneering capability lies in its automated process of designing, synthesizing, and testing at an unprecedented scale. Our groundbreaking approach enables us to iterate our design cycle using trillions of proprietary experimental data points across an astronomical drug-like chemical space which we believe sets an entirely new standard for the application of scalable machine learning to drug design.”
– Tim Craven, CEO and co-founder of Insamo
“Insamo represents Playground’s commitment to investing in companies that apply proprietary data for AI and machine learning in underexplored domains. Through an AI and ML-driven drug discovery platform, Insamo is developing macrocycles using massively scaled in-house data. Macrocycles are a natural and uniquely efficacious modality, and, powered by Insamo’s AI-driven engineering, they can create safer and more potent oral therapeutics. Insamo’s technology unlocks the potential to engineer macrocycles with improved properties and develop new therapies for previously undruggable targets across a broad range of diseases with high unmet need.”
– Playground Global’s Matt Hershenson
“This innovative platform truly discovers membrane-permeable cyclic-peptides with oral bioavailability and binding capabilities akin to monoclonal antibodies. The company’s capacity to synthesize and screen libraries containing trillions of molecules facilitates the discovery of high-affinity ligands for drug targets across a spectrum of diseases. Our investment in Insamo underscores our dedication to supporting companies pushing the boundaries of drug discovery to enhance patient outcomes.”
– Dr. Corey Goodman, co-founder of venBio
